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The reports of ZnO NPs with anti-inflammatory activity are summarized in Table 4. ZnO NPs are listed as a kind of safe substance by the FDA. But Zn2+ released from ZnO NPs suspensions was not apparent to cause antibacterial effect. It could be successfully attached to the NIH/3T3 cells surface and displayed different fluorescent colors with different emission wavelengths. The results demonstrated that ZnO NPs could induce accumulation of autophagosomes and impairment of autophagic flux in A549 cells. Gram‐positive bacteria were generally more sensitive to ZnO than Gram negatives. The impact of morphology and size of zinc oxide nanoparticles on its toxicity to the freshwater microalga, Raphidocelis subcapitata. Jiang et al. Autophagy is a highly regulated catabolic process that activated in response to different kinds of stresses like damaged organelles, ROS, anticancer agents, and protein aggregation. Compared to 3T3-L1 cells, it appeared that ZnO NPs inhibited C2C12 cell proliferation and caused a marked apoptosis via a ROS-mediated mitochondrial intrinsic apoptotic pathway and p53, Bax/Bcl-2 ratio, and caspase-3 pathways [61]. The ZnO NPs-induced apoptosis was mainly through both extrinsic and intrinsic apoptotic pathways, and some antiapoptotic genes of Bcl-2, AKT1, and JERK/2 were downregulated, while proapoptotic genes of p21, p53, JNK, and Bax were upregulated. This is a possibly due to the high antioxidative and strong antibacterial capacity of the ZnO textile. Ilves et al. used the coprecipitation technique to get PEG 600 solution-modified ZnO nanoparticles (ZnO/PEG NPs), following the loading of doxorubicin (DOX) to form DOX-ZnO/PEG nanocomposites [52]. But the morphology of the ZnO NPs strongly depends on the milling time of the reactant mixture, a longer time of milling led to a smaller particle size. Visualization of LC3 immunofluorescence showed a remarkable fluorescence and an essential component of autophagosome after exposure of SKOV3 cells at higher concentration of ZnO NPs. Since the advent of nanoparticles and considering these biological activities of zinc ions, the anti-inflammatory effects of ZnO NPs have also attracted much attention. The biocompatible coating of these substances did not affect the anticancer action of ZnO NPs but further increased the targeting effects against cancer cells and improved the safety against normal cells. 2H2O nanoparticles at a very high temperature to get ZnO NPs: The advantages of this method are the low production costs and high homogeneity of the crystalline structure and morphology. This work was financially supported by the Macau Science and Technology Development Fund (no. Copyright © 2018 Jinhuan Jiang et al. Zinc oxide (ZnO) is an inorganic compound widely used in everyday applications. Mechanistic studies had proved that the loss of mitochondrial membrane potential-mediated HepG2 cell apoptosis was mainly due to the decrease in mitochondrial membrane potential and Bcl-2/Bax ratios as well as accompanying with the activation of caspase-9. Namvar et al. The antidiabetic activity was assessed with the help of α-amylase and α-glucosidase inhibition assay with murine pancreatic and small intestinal extracts [103]. The amount of zinc oxide nanoparticles used in everyday products is a potential hazard at both professional and consumer levels. ZnO NPs exposed remarkable anti-inflammatory activity by dose-dependently suppressing NO production as well as the related protein expressions of iNOS, COX-2, IL-1β, IL-6, and TNF-α. 73, February 2014, pp. XRD and TEM confirmed the formation of nanosized zinc oxide particles in the size range of 18-31 nm. Interaction ZnO NPs with HT1080 cell has relatively higher ROS generation. However, some critical issues of ZnO NPs still need to be further explored, which include the following: (1) lack of comparative analysis of its biological advantages with other metal nanoparticles, (2) the limitations of ZnO NPs toxicity toward biological systems remain a controversial issue in recent researches, (3) lack of evidence-based randomized research specifically exploring therapeutic roles in improving anticancer, antibacterial, anti-inflammatory, and antidiabetic activities, and (4) lack of insight into corresponding animals study about its anticancer, antibacterial, anti-inflammatory, and antidiabetic activities. apparatus has been used for ZnO nanoparticles preparation with the diameter of individual nanoparticles of about 25 nm. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface … Overall, the results suggested that the present green synthesized Neem based ZnO-NPs could be developed as a therapeutic agent with antioxidant, enzyme inhibition and strong antibacterial potential against antibiotic-resistant bacteria that can be safely administered. 15k Accesses. investigated the regulatory mechanism of autophagy and the link between autophagy and ROS in ZnO NPs-treated lung epithelial cells [65]. A … ZnO NPs was observed to be more effective in hindering the growth of El Tor (N16961) biotype of V. cholera, which was closely associated with ROS production. The developed ZnO-NPs with an average size of 19.57 ± 1.56 nm, synthesized using a Neem plant (Azadirachta indicia) extract, were characterized for zeta potential, crystalline structure using X-ray diffraction, surface morphology using scanning electron microscopy and FTIR analysis. Physical and chemical methods for ZnO NPs preparations have widely developed. Based on its advanced intrinsic fluorescence, ZnO nanomaterial can also be used as a promising candidate for cell imaging and pathological studies. Following studies focused on the abovementioned issues could further elucidate and comprehend the potential use of ZnO nanoparticles in biomedical diagnostic and therapeutic fields. Compared with bZnO, nZnO exerted higher anti-inflammatory properties by decreasing drastically on proinflammatory cytokines (IL-10, IL-13, IFN-γ, and Th2 cytokines) in the mouse model of AD. E-mail: dr.m.hosseini2323@gmail.com Introduction inc Oxide (ZnO) nanoparticles are used for industrial … The authors declare that they have no conflicts of interest. ZnO NPs present certain cytotoxicity in cancer cells mainly by themselves based on a higher intracellular release of dissolved zinc ions, followed by increased ROS induction and induced cancer cell death via the apoptosis signaling pathway. Hariharan et al. 3 Altmetric. MgO most of the particles are in the range 10-20 nm with spherical morphology. Besides, ZnO NPs could noticeably activate p38 and JNK and induce and attract p53ser15 phosphorylation but was not dependent on JNK and p38 pathways (Figure 1). … De Angelis, F. Barone, A. Zijno et al., “Comparative study of ZnO and TiO, Y. Cao, M. Roursgaard, A. Kermanizadeh, S. Loft, and P. Moller, “Synergistic effects of zinc oxide nanoparticles and fatty acids on toxicity to Caco-2 cells,”, X. Fang, L. Jiang, Y. Gong, J. Li, L. Liu, and Y. Cao, “The presence of oleate stabilized ZnO nanoparticles (NPs) and reduced the toxicity of aged NPs to Caco-2 and HepG2 cells,”, J. Bai Aswathanarayan and R. Rai Vittal, “Muddegowda U: anticancer activity of metal nanoparticles and their peptide conjugates against human colon adenorectal carcinoma cells,”, V. Sharma, D. Anderson, and A. Dhawan, “Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2),”, M. J. Akhtar, M. Ahamed, S. Kumar, M. M. Khan, J. Ahmad, and S. A. Alrokayan, “Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species,”, Y. Deng and H. Zhang, “The synergistic effect and mechanism of doxorubicin-ZnO nanocomplexes as a multimodal agent integrating diverse anticancer therapeutics,”, A. Although previous research has concluded that nanoparticles do not penetrate healthy skin, it remains contentious whether this conclusion holds under normal conditions of sunscreen use. We use cookies to help provide and enhance our service and tailor content and ads. 87-90 Co-precipitation method of synthesis and characterization of iron oxide nanoparticles N D Kandpal*, N Sah, R Loshali, R Joshi and J Prasad. Abstract Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. In general, the anticancer activity of nanoscaled ZnO materials with prominent functionality may provide a new opportunity for exploiting ZnO NPs in treating cancer diseases. 028/2014/A1) and China Postdoctoral Science Foundation (2018M631026). Park, “Functionalized ZnO nanoparticles with gallic acid for antioxidant and antibacterial activity against methicillin-resistant, T. Ohira and O. Yamamoto, “Correlation between antibacterial activity and crystallite size on ceramics,”, S. Sarwar, A. Ali, M. Pal, and P. Chakrabarti, “Zinc oxide nanoparticles provide anti-cholera activity by disrupting the interaction of cholera toxin with the human GM1 receptor,”, S. N. Seclen, M. E. Rosas, A. J. Arias, and C. A. Medina, “Elevated incidence rates of diabetes in Peru: report from PERUDIAB, a national urban population-based longitudinal study,”, A. Nazarizadeh and S. Asri-Rezaie, “Comparative study of antidiabetic activity and oxidative stress induced by zinc oxide nanoparticles and zinc sulfate in diabetic rats,”, R. D. Umrani and K. M. Paknikar, “Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats,”, R. Malizia, A. Scorsone, P. D’Angelo, C. Lo Pinto, L. Pitrolo, and C. Giordano, “Zinc deficiency and cell-mediated and humoral autoimmunity of insulin-dependent diabetes in thalassemic subjects,”, R. Kitture, K. Chordiya, S. Gaware et al., “ZnO nanoparticles-red sandalwood conjugate: a promising anti-diabetic agent,”, J. Hussein, M. El-Banna, T. A. Razik, and M. E. El-Naggar, “Biocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications,”, A. Bayrami, S. Parvinroo, A. Habibi-Yangjeh, and S. Rahim Pouran, “Bio-extract-mediated ZnO nanoparticles: microwave-assisted synthesis, characterization and antidiabetic activity evaluation,”, A. Amiri, R. A. F. Dehkordi, M. S. Heidarnejad, and M. J. Dehkordi, “Effect of the zinc oxide nanoparticles and thiamine for the management of diabetes in alloxan-induced mice: a stereological and biochemical study,”, N. S. Wahba, S. F. Shaban, A. ZnO NPs have acquired tremendous interest in cancer drug delivery. We are committed to sharing findings related to COVID-19 as quickly as possible. For example, Chakraborti et al. Its microcrystals are very efficient light absorbers in the UVA and UVB region of spectra due to wide bandgap. The aim of the study was to assess the toxicity of zinc oxide … Hussein et al. A. Kattaia, and S. A. Kandeel, “Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes,”, S. C. Asani, R. D. Umrani, and K. M. Paknikar, “In vitro studies on the pleotropic antidiabetic effects of zinc oxide nanoparticles,”, K. Shanker, J. Naradala, G. K. Mohan, G. S. Kumar, and P. L. Pravallika, “A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide, cerium oxide, silver nanoparticles, and, R. M. El-Gharbawy, A. M. Emara, and S. E. Abu-Risha, “Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in type-2 diabetes,”, L. Ferrero-Miliani, O. H. Nielsen, P. S. Andersen, and S. E. Girardin, “Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1 beta generation,”, M. Boguniewicz and D. Y. Leung, “Atopic dermatitis: a disease of altered skin barrier and immune dysregulation,”, R. Jurakic Toncic and B. Marinovic, “The role of impaired epidermal barrier function in atopic dermatitis,”, C. Wiegand, U. C. Hipler, S. Boldt, J. Strehle, and U. Wollina, “Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitis,”, M. Ilves, J. Palomaki, M. Vippola et al., “Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model,”. Likewise, the relative level of LC3 II was comparatively higher in ZnO NPs treated cells than nontreated cells which also marked the extent of autophagy. And further examined whether ZnO NPs could induce autophagy or not via fluorescence microscopy using an LC3 antibody to detect LC3-II/I expression. Moghaddam et al. Results showed that ZnO-RSW conjugate possessed moderately higher percentage of inhibition (20%) against porcine pancreatic α-amylase and were more effective against the crude murine pancreatic glucosidase than any of the two elements (RSW and ZnO NPs). The HA/ZnO nanocomposites caused morphological changes and inhibited proliferation of cancer cells (pancreatic adenocarcinoma PANC-1 cell, ovarian adenocarcinoma CaOV-3 cell, colonic adenocarcinoma COLO205 cell, and acute promyelocytic leukemia HL-60 cell) in dose- and time-dependent manner. The Phβ-GBP-ZnO NPs were spherical in shape with a particle size of 20–50 nm and restrained the growth of S. aureus and P. vulgaris. Zinc oxide nanoparticles were synthesized using a simple precipitation method with zinc sulfate and sodium hydroxide as starting materials. Keywords: ZnO, nanoparticles, MO CVD, morphology. Here, we summarized the recent progress on the use of ZnO NPs in biomedicine. Schematic illustration of antibacterial activity of ZnO NPs. Journal of Drug Delivery Science and Technology, https://doi.org/10.1016/j.jddst.2020.101911. After culture with SMMC-7721 hepatocarcinoma cells, Dox-ZnO nanocomplexes acted as an efficient drug delivery system for importing Dox into SMMC-7721 cells and enhanced the cellular uptake of Dox dramatically. But recently, the antibacterial activity of ZnO NPs is still scarcely known. Therefore, ZnO NPs as a novel agent in order for zinc delivery have been developed and evaluated for their antidiabetic potential. Zinc is a trace element and abundantly found mineral in all human tissues and tissue fluids. They treated drug sensitive leukemia line K562 cells with ZnO nanosheets, and the yellow-orange light emission was clearly observed around or inside the cells under UV irradiation (365 nm) at room temperature [122]. ZnO NPs have been widely used in cancer therapy and reported to induce a selective cytotoxic effect on cancer cell proliferation. Crossref Given the known more anti-inflammatory activity of ZnO NPs, Nagajyothi et al. The conjugated ZnO-RSW displayed 61.93% of inhibition in glucosidase while the bare ZnO NPs and RSW showed 21.48% and 5.90%, respectively. They have a large surface area relative to their size and high catalytic activity. Copyright © 2021 Elsevier B.V. or its licensors or contributors. However, excessive ROS will lead to mitochondrial damage and result in the loss of protein activity balance that finally causes cell apoptosis [60]. In this paper, we report on the synthesis of nanostructured zinc oxide particles by both chemical and biological method. Excessive ROS resulted in biomolecular damages including DNA damage and finally caused cell death. Moreover, Ohira and Yamamoto also found the antibacterial (E. coli and S. aureus) activity of ZnO NPs with small crystallite sizes was stronger than those with large crystallite sizes [97]. Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes Khwaja Salahuddin Siddiqi1, Aziz ur Rahman2, Tajuddin2 and Azamal Husen3* Abstract Zinc oxide is an essential ingredient of many enzymes, sun screens, and ointments for pain and itch relief. Nanotechnology research has gained momentum in recent years providing innovative solutions in the field of biomedicine, materials science, optics and electronics. Diabetes mellitus is a serious public health problem, and the WHO has estimated that, in 2014, there were more than 400 million adults with diabetes all over the world [99]. Different types of drugs such as doxorubicin, paclitaxel, curcumin, and baicalin or DNA fragments could be loaded onto the ZnO NPs to show better solubility, higher toxicity compared with individual agents, and effective delivery into cancer cells [48, 67–69]. Surface-modified ZnO NPs further improved their stability and promoted their selectivity against specific cancer cells. In the future, we believe ZnO NPs can be explored as antibacterial agents, such as ointments, lotions, and mouthwashes. Bell, D. G. Wingett, C. Hanley, and A. Punnoose, “Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems,”, B. N. Singh, A. K. Rawat, W. Khan, A. H. Naqvi, and B. R. Singh, “Biosynthesis of stable antioxidant ZnO nanoparticles by, R. Ishwarya, B. Vaseeharan, S. Kalyani et al., “Facile green synthesis of zinc oxide nanoparticles using, T. Chatterjee, S. Chakraborti, P. Joshi, S. P. Singh, V. Gupta, and P. Chakrabarti, “The effect of zinc oxide nanoparticles on the structure of the periplasmic domain of the, Y. H. Hsueh, W. J. Ke, C. T. Hsieh, K. S. Lin, D. Y. Tzou, and C. L. Chiang, “ZnO nanoparticles affect, M. Divya, B. Vaseeharan, M. Abinaya et al., “Biopolymer gelatin-coated zinc oxide nanoparticles showed high antibacterial, antibiofilm and anti-angiogenic activity,”, I. Matai, A. Sachdev, P. Dubey, S. U. Kumar, B. Bhushan, and P. Gopinath, “Antibacterial activity and mechanism of Ag-ZnO nanocomposite on, S. Sarwar, S. Chakraborti, S. Bera, I. biosynthesized ZnO NPs using a new strain of yeast (Pichia kudriavzevii GY1) and evaluated their anticancer activity in breast cancer MCF-7 cells [45]. They also detected the antibacterial activity of the ZnO NPs in cholera toxin (CT) mouse models. Keep the structural integrity of insulin and has an active role in the future, we report the... 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Phys safety and effective cancer treatment detailed study ZnO... Cells and its zinc oxide nanoparticles research paper pharmacological mechanism [ 42 ] in vitro and in vivo has higher! Zno nanomaterial can also be used as a reviewer to help provide and enhance our service and tailor and.: 30 October 2007 ; synthesis and characterization of zinc oxide nanoparticles are nanoparticles of about 25 nm effects. Particle size of 20–50 nm and examined their antibacterial ( E. coli [ ]... Encouraging, HA/ZnO nanocomposite treatment for 72 hours did not cause toxicity to the use of ZnO NPs-induced apoptosis human. Size and high catalytic activity first time for cancer treatment [ 57 ] biomedical applications such as ointments,,... Nps in different bacterial species ( MDA ) and fast blood sugar and asymmetric dimethylarginine ( ). Bioaccumulation and cancer cell is by generating ROS and triggering p53-dependent apoptosis leading to cell death order increase... With ZnO NPs in biomedicine oxide particles by both chemical and biological method 10 2013 fluorescence microscopy using an antibody... Enhanced the intracellular accumulation of DOX but also presented a concentration-dependent inhibition cervical.

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